Research in the Department of Medicinal Chemistry

Discovery and development of new natural or synthetic organic compounds of biomedical utility is a critical component of medicinal chemical research. The Department of Medicinal Chemistry at the University of Kansas is among the pioneering departments to have focused on organic synthesis as a core area of its research activity. Since the days of its inception in the 1960s, the Department has been blessed with faculty members whose often-trailblazing ideas and research activities, both organic synthetic and medicinal chemical, have helped shape contemporary medicinal chemistry to its present state. More recently, research in the Department has expanded into the areas of biochemistry/peptide chemistry/chemical biology emphasizing the interactions of small molecules and peptides with larger biomolecules such as proteins and lipopolysaccharides. Working at the interface between chemistry and biology, researchers in the Department focus on the design, synthesis, and biological characterization of new and existing drugs as they interact with receptors and other cellular biochemical systems.

Research Areas

Training Grants

 

NIH COBRE Centers

  • The Chemical Biology of Infectious Diseases Center (CBID) focuses on chemical biology and the involvement of the discovery of chemical entities able to modulate pathways related to infectious processes. Such work can lead to an increase in biological understanding and the identification of novel targets for chemical intervention. This research can provide leads for downstream drug discovery efforts.
  • The Center for Molecular Analysis of Disease Pathways (CMADP) brings together junior and senior faculty at the University of Kansas and other academic institutions in Kansas to conduct multidisciplinary research to develop and implement cutting-edge technologies for elucidating the genetic, chemical, and physical mechanisms of biological processes involved in disease. The research could result in enabling technologies that can be employed to identify new therapeutic targets.
  • The COBRE Center in Protein Structure and Function (PSF)unites researchers from the University of Kansas and other Kansas academic institutions to conduct health-related basic research in protein structure and function. Through this research, scientists gain a deeper understanding of how proteins do the work of the cell. This understanding could eventually lead to the development of new and improved drugs.

Facilities and Core Laboratories

Please visit this listing of Core Laboratories available on The University of Kansas campus.

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