Mark Farrell

  • Assistant Professor
School of Pharmacy - Medicinal Chemistry
785-864-6234
Office
Shankel Stuctural Biology Center
2030 Becker Drive
Lawrence 66047

Education

  • Ph.D., Synthetic Organic Chemistry, National University, Ireland
  • B.S., Chemistry, 1st Class Honours, National University, Ireland

Selected Publications

Influence of acyl groups on glucopyranoside reactivity in Lewis acid promoted anomerizations. Tett. Lett., 2018, 59, 2727-2731.

Herschhorn, A. Gu, C. Moraca, F. Ma, X. Farrell, M. Smith, A. B., Pancera, M. Kwong, P. D., Schön, A. Freire, E. Abrams, C. Blanchard, S. C., Mothes, W. & Sodroski, J. G. (2017). The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions. Nature Communications, 8(1), 1049. DOI:10.1038/s41467-017-01119-w https://doi.org/10.1038/s41467-017-01119-w

Farrell, M. Melillo, B. & Smith, A. B. (2016). Type II Anion Relay Chemistry: Exploiting Bifunctional Weinreb Amide Linchpins for the One-Pot Synthesis of Differentiated 1,3-Diketones, Pyrans, and Spiroketals. Angew. Chem. Int. Ed, 55, 232-235.

Farrell, M. O'Reilly, C. Venkatrao Jarikote, D. & Murphy, P. V. (2014). Ultrasonic Energy Promoted Allylation to Generate 1-C-(2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl)prop-2-ene. Carbohydrate Chemistry: Proven Synthetic Methods, 2.

Breen, E. P., Pilgrim, W. Clarke, K. J., Yssel, C. Farrell, M. Zhou, J. Murphy, P. V., & Porter, R. K. (2013). Lack of Activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths. J. Chem. Biol, 6, 121-133.

Farrell, M. Zhou, J. & Murphy, P. V. (2013). Regiospecific anomerisation of acylated glycosyl azides and benzoylated disaccharides using TiCl4. Chem. Eur. J, 13, 14836-14851

Gerlach, J. Kilcoyne, M. Farrell, M. Kane, M. & Joshi, L. (2012). Differential release of high mannose structural isoforms by fungal and bacterial endo-β-N-acetylglucosaminidases. Mol. BioSyst, 8, 1472-1481

Kilcoyne, M. Gerlach, J. Farrell, M. Bhavanandan, V. & Joshi, L. (2011). Periodic acid-Schiff’s reagent assay for carbohydrates in a microtiter plate format. Anal. Biochem, 1, 18-26

Awards & Honors

  • Boc gas Postgraduate Student of the Year (2014)
  • Galway Graduate Symposium Winner, Eli-Lilly NUI (2012)
  • IRCSET Enterprise Ph.D. Fellowship (2010)
  • SFI UREKA (Undergraduate Research Experience & Knowledge Award) Scholarship (2009)

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