Robert Hanzlik

  • Professor Emeritus
School of Pharmacy - Medicinal Chemistry
785-864-3750
Office
1084 Structural Biology Center
2034 Becker Drive
Lawrence, KS 66047

Education

  • Ph.D., Organic Chemistry, Stanford University
  • B.A., Chemistry and Biology, Southern Illinois University at Carbondale

Selected Publications

Keisuke Ikehata, Tatyana G. Duzhak, Nadezhda A. Galeva, Tao Ji, Yakov M. Koen and Robert P. Hanzlik, "Protein Targets of Reactive Metabolites of Thiobenzamide in Rat Liver In Vivo." Chem. Res. Toxicol., 2008, 21, 1432–1442. PMID: 18547066

Kristin Bowman-James, Gary L. Grunewald and Robert P. Hanzlik, "Eulogy to Mathias P. Mertes, 1932-1989." Med. Res. Rev. 29(1),1-2 (2009).

Robert P. Hanzlik, Jianwen Fang, Yakov M. Koen, "Filling and Mining the Reactive Metabolite Target Protein Database," Chem.-Biol. Interactions, 179, 38-44 (2009). PMID: 18823962 PMC2669808

M. A. Altaweel, J. Ver Hoeve, J. Eells, R. P. Hanzlik and B. Zhang, "Ocular and Systemic Safety Evaluation of Calcium Formate." J. Ocular Pharmacol. Toxicol. 25, 223-230 (2009). PMID: 19456257

Jianwen Fang, Yakov Koen and Robert P. Hanzlik, "Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners."  BMC Chemical Biology 2009, 9:5 (12 June 2009).  PMID: 19523227

Douglas S. Auld, Scott Lovell, Natasha Thorne, Wendy A. Lea, David J. Maloney, Min Shen, Ganesha Rai, Kevin Battaile, Craig J. Thomas, Anton Simeonov, Robert P. Hanzlik,  and James Inglese, "Molecular Basis for the High Affinity Binding and Stabilization of Firefly Luciferase by PTC124." Proc. Nat. Acad. Sci. USA 2010, 107, 4878-83.  PMID 20194791

Diganta Sarma and Robert P. Hanzlik, "Synthesis of carbon-14, carbon-13 and deuterium labeled thioacetamide and thioacetamide S-oxide" Journal of Labelled Compounds and Radiopharmaceuticals, 54, 795-798 (2011).  PMID: 22667464

Yakov M. Koen, Diganta Sarma,aTodd D. Williams, Nadezhda A. Galeva, R. Scott Obach and Robert P. Hanzlik, "Identification of Protein Targets of Reactive Metabolites of Tienilic Acid in Human Hepatocytes." Chem. Res. Toxicol. 25, 1145-54 (2012).   PMID: 22462724 http://dx.doi.org/10.1021/tx3001658    

Yakov M. Koen, Heather Hajovsky, Ke Liu, Todd D. Williams, Nadezhda A. Galeva# Jeffrey L. Staudinger and Robert P. Hanzlik, "Liver Protein Targets of Hepatotoxic 4-Bromophenol Metabolites."  Chem. Res. Toxicol. 25, 1777-1786 (2012).  http://dx.doi.org/10.1021/tx3002675  PMC3431021

Diganta Sarma, Heather Hajovsky, Yakov M. Koen, Nadezhda A. Galeva, Todd D. Williams, Jeffrey L. Staudinger, and Robert P. Hanzlik, "Covalent Modification of Lipids and Proteins in Rat Hepatocytes and in Vitro by Thioacetamide Metabolites."  Chem. Res. Toxicol., 25, 1868–1877 (2012).  http://dx.doi.org/10.1021/tx3001658   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444623/

Liz Hajovsky, Gang Hu, Yakov Koen, Diganta Sarma, Wenqi Cui, David S. Moore, Jeff L. Staudinger and Robert P. Hanzlik, "Metabolism and Toxicity of Thioacetamide and Thioacetamide S-Oxide in Rat Hepatocytes."   Chem. Res. Toxicol. 25, 1955-1963 (2012).  http://dx.doi.org/10.1021/tx3002719  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444651/

Yakov M. Koen, Diganta Sarma, Heather Hajovsky, Nadezhda A. Galeva, Todd D. Williams, Jeffrey L. Staudinger and Robert P. Hanzlik, "Protein Targets of Thioacetamide Metabolites in Rat Hepatocytes" Chem. Res. Toxicol. 26, 564−574 (2013).  dx.doi.org/10.1021/tx400001x.  PMID 23465048    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710294/

Robert P. Hanzlik; Yakov M. Koen; Jianwen Fang, "Bioinformatic Analysis of 302 Reactive Metabolite Target Proteins.  Which Ones Are Important for Cell Death?" Toxicological Sciences, 135, 390-401 (2013)  doi: 10.1093/toxsci/kft166 

Pinakin Sukthankar , L. Adriana Avila, Susan K. Whitaker, Takeo Iwamoto, Alfred Morgenstern, Christos Apostolidis,  Ke Liu, Robert P. Hanzlik, Ekaterina Dadachova, JohnM. Tomich, "Branched amphiphilic peptide capsules: Cellular uptake and retention of encapsulated solutes" Biochimica et Biophysica Acta 1838, 2296-2305 (2014). http://dx.doi.org/10.1016/j.bbamem.2014.02.005

Yakov M. Koen, Nadezhda A. Galeva, Imir G. Metushi, Jack Uetrecht, and Robert P. Hanzlik, “Protein Targets of Isoniazid-Reactive Metabolites in Mouse Liver in Vivo.” Chem. Res. Toxicol. 2016, 29, 1064−1072.  http://pubs.acs.org/doi/abs/10.1021/acs.chemrestox.6b00098

Goldman, J.L, Koen, Y,M., Rogers, S., Li, K., Leeder, S.L., Hanzlik, R. P., “Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes,”Drug Metab. Dispos. 44:1603–1607 (2016).  PMID:27457783

Yakov M. Koen, Ke Liu, Heather Shinogle, Todd D. Williams, and Robert P. Hanzlik, “Comparative Toxicity and Metabolism of N‑Acyl Homologues ofAcetaminophen and Its Isomer 3′-Hydroxyacetanilide.” Chem Res Toxicol. 29, 1857-1864 (2016).   PMID:27680534

Lan Lan, Minli Xing, Justin Douglas, Philip Gao, Robert P. Hanzlik, Liang Xu, "Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket." Oncotarget. 2017, 8(63), 106587-106597. PMID: 29290973 PMCID: PMC5739758 DOI: 10.18632/oncotarget.22540

Lan Lan, Minli Xing, Maithri M. Kashipathy, Justin T. Douglas, Philip Gao, Kevin P. Battaile, Robert P. Hanzlik, Scott Lovell, and Liang Xu. Crystal and Solution Structures of Human Oncoprotein Musashi-2 N-terminal RNA Recognition Motif 1. Proteins. 2019;1–11.  DOI: 10.1002/prot.25836


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