Jingxin Wang
- Assistant Professor
School of Pharmacy - Medicinal Chemistry
785-864-1254
Office
Structural Biology Center, Room 2058
University of Kansas
2034 Becker Drive
Lawrence, KS 66047
Education
- Postdoctoral Fellow, Johns Hopkins University (2014) and Scripps Research Institute (2019)
- Ph.D., Chemistry, University of Maryland (2011)
- B.S., Chemistry, Peking University (2006)
Research Overview
The Wang laboratory is focused on:
- A novel pharmacological modality of modulating RNA splicing by small molecules
- Exploring new approaches to regulate innate immune response in mammalian cells.
Selected Publications
Rapafucins, rapamycin-inspired macrocycles with new target specificity. (2019) Nat. Chem.,11(3):254-63. Guo ZF#, Hong SY#, Wang J#, Rehan S, Liu W, Peng H, Das M, Li W, Bhat S, Peiffer B, Ullman BR, Tse CM, Tarmakova Z, Schiene-Fischer C, Fischer G, Coe I, Paavilainen VO, Sun Z, Liu JO. (# = co-first authors).
Mechanistic studies of a small molecule modulator of SMN2 splicing, PNAS, 115(20): E4604-12. (2018) Wang J, Schultz PG, Johnson K.
Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins. J. Am. Chem. Soc. 133(24):9320-90. (2011) Wang J, Zhou J, Donaldson GP, Nakayama S, Yan L, Lam YF, Lee VT, Sintim HO.
