Publications

Independent Career

  1. Exploiting the Unusual Effects of Fluorine in Methodology Orsi, D. L.; Altman, R. A. Chem. Commun. 2017, Manuscript Accepted.

    Invited "Feature Article" for Emerging Investigators Issue

  1. Base Catalysis Enables Access to α,α-Difluoroalkylthioethers Orsi, D. L.; Easley, B. J.; Lick, A. M.; Altman, R. A.Org. Lett. 2017, 19, 1570–1573.

  1. Synthesis and Opioid Activity of Tyr1–ψ[(Z)CF=CH]–Gly2 and Tyr1–ψ[(S)/(R)-CF3CH–NH]–Gly2 Leu-enkephalin Fluorinated Peptidomimetics Karad, S. N.; Pal, M.; Crowley, R. S.; Prisinzano, T. E.; Altman, R. A. ChemMedChem 2017, 12, 571–576.

  1. Metal-Catalyzed Decarboxylative Fluoroalkylation Reactions Ambler, B. A.; Yang, M.-H.; Altman, R. A. Synlett 2016, 27, 2747–2755.

    Invited "Synpacts" Contribution

  1. Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates Yang, M.-H.; Hunt, J. R.; Sharifi, N. Altman, R. A. Angew. Chem. Int. Ed. 2016, 55, 9080–9083.

  1. Copper-Catalyzed Synthesis of Trifluoroethylarenes from Benzylic Bromodifluoroacetates Ambler, B. R.; Zhu, L.; Altman, R. A. J. Org. Chem. 2015, 80, 8449–8457.

  1. Ligand-controlled Regioselective Cu-Catalyzed Trifluoromethylation to Generate Trifluoromethyl Allenes Ambler, B. R.; Peddi, S.; Altman, R. A. Org. Lett. 2015, 17, 2506–2509.

  1. Ligand-Controlled Regiodivergent Palladium-Catalyzed Decarboxylative Allylation Reaction to Access α,α-Difluoroketones Yang, M.-H.; Orsi, D. L.; Altman, R. A. Angew. Chem. Int. Ed. 2015, 54, 2361–2365.

  1. Metal-free Trifluoromethylation of Aromatic and Heteroaromatic Aldehydes and Ketones Qiao, Y.; Si, T.; Yang, M.-H.; Altman, R. A. J. Org. Chem. 2014, 79, 7122–7131.

  1. Copper-catalyzed Conversion of Propargylic Bromodifluoroacetates to Trifluoromethanes Ambler, B. R.; Peddi, S.; Altman, R. A. Synthesis 2014, 46, 1938–1946.

    Special Topics Issue on Copper and Nickel Chemistry

  1. Decarboxylative Fluorination Strategies for Accessing Medicinally-Relevant Products Qiao, Y.; Zhu, L.; Ambler, B. R.; Altman, R. A. Curr. Top. Med. Chem. 2014, 14, 966–978.

  1. Copper-Catalyzed Decarboxylative Trifluoromethylation of Allylic Bromodifluoroacetates Ambler, B. R.; Altman, R. A. Org. Lett. 2013, 15, 5578–5581.

  1. Copper-Mediated Deoxygenative Trifluoromethylation of Benzylic Xanthates: Formation of C(sp3)-CF3 through Nucleophilic Substitution Zhu, L.; Liu, S.; Altman, R. A. Chem. Eur. J. 2013, 19, 12800–12805.

  1. Preparation of Fluoroalkenes via the Shapiro Reaction: Direct Access to Fluorinated Peptidomimetics Yang, M. H.; Matikonda, S. S.; Altman, R. A. Org. Lett. 2013, 15, 3894–3897.

    Highlighted in Chemical & Engineering News:  "Chemists Give Peptidomimetics an F"

Graduate and Postdoctoral Publications

  1. “Total Synthesis of (+)-Nankakurines A and B and Synthesis of (±)-5-epi-Nankakurine A” Altman, R. A.; Nilsson, B. N.; Overman, L. E.; Read de Alaniz, J., Rohde, J. M.; Taupin, V. J. Org. Chem. 2010, 75, 7519–7534.
  2. “Palladium-catalyzed Enantioselective α-Arylation and α-Vinylation of Oxindoles Facilitated by an Axially Chiral P-Stereogenic Ligand" Taylor, A. M.; Altman, R. A.; Buchwald, S. L. J. Am. Chem. Soc. 2009, 131, 9900–9901.
  3. “Orthogonal Pd- and Cu-Based Catalyst Systems for the C- and N-Arylation of Oxindoles” Altman, R. A.; Hyde, A. M.; Huang, X.; Buchwald, S. L. J. Am. Chem. Soc. 2008, 130, 9613–9620.
  4. “Pyrrole 2-Carboxylic Acid as a Ligand for the Cu-Catalyzed Reactions of Primary Anilines with Aryl Halides” Altman, R. A.; Anderson, K. W.; Buchwald, S. L. J. Org. Chem. 2008, 73, 5167–5169.
  5. “An Improved Cu-Based Catalyst System for the Reactions of Alcohols with Aryl Halides” Altman, R. A.; Shafir, A.; Choi, A. C.; Lichtor, P. A.; Buchwald, S. L. J. Org. Chem. 2008, 73, 284–286.
  6. “Pd-Catalyzed Suzuki-Miyaura Reactions of Aryl Halides Using Bulky Biarylmonophosphine Ligands” Altman, R. A.; Buchwald, S. L. Nature Prot. 2007, 2, 3115–3121.
  7. “Pd-Catalyzed Amination Reactions of Aryl Halides Using Bulky Biarylmonophosphine Ligands” Altman, R. A.; Buchwald, S. L. Nature Prot. 2007, 2, 2881–2887.
  8. “Cu-Catalyzed Goldberg and Ullmann Reactions of Aryl Halides Using Diamine and b-Diketone Ligands” Altman, R. A.; Buchwald, S. L. Nature Prot. 2007, 2, 2474–2479.
  9. “Copper-Catalyzed N-Arylation of Imidazoles and Benzimidazoles” Altman, R. A.; Koval, E. D.; Buchwald, S. L. J. Org. Chem. 2007, 72, 6190–6199.
  10. “Cu-Catalyzed N- and O-Arylation of 2-, 3- and 4-Hydroxypyridines and Hydroxyquinolines” Altman, R. A.; Buchwald, S. L. Org. Lett. 2007, 9, 643–646.
  11. “Monodentate Phosphines Provide Highly Active Catalysts for Pd-Catalyzed C–N Bond-Forming Reactions of Heteroaromatic Halides/Amines and (H)N-Heterocycles” Anderson, K. W.; Tundel, R. E.; Ikawa, T.; Altman, R. A.; Buchwald, S. L. Angew. Chem. Int. Ed. 2006, 45, 6523–6527.
  12. “4,7-Dimethoxy-1,10-phenanthroline: An Excellent Ligand for the Cu-Catalyzed N-Arylation of Imidazoles” Altman, R. A.; Buchwald, S. L. Org. Lett. 2006, 8, 2779–2782.

 

Minor Works

  1. “Editorial: Fluorination and Fluorinated Compounds in Medicinal Chemistry” Altman, R. A. Curr. Top. Med. Chem. 2014, 7, 837–839.
  2. “3,4,7,8-Tetramethyl-1,10-Phenanthroline (tmphen)” Zhu, L.; Altman, R. A.  Electronic Encyclopedia of Reagents Organic Synthesis [Online]; John Wiley & Sons, Ltd., Published Online April 22, 2013.​
  3. “10-Phenanthroline, 4,7-Dimethoxy-” Altman, R. A.  Electronic Encyclopedia of Reagents Organic Synthesis [Online]; John Wiley & Sons, Ltd., Posted September 15, 2008.

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