Barbara Timmermann Research

  • B.S., Universidad Nacional de Cordoba, Argentina Biology, 1970
  • M.S., University of Texas, Austin, Botany (Phytochemistry), 1977
  • Ph.D., University of Texas, Austin, Botany (Phytochemistry), 1980
  • Research Associate, University of Arizona, 1981-1985
  • Assistant Professor, Associate Professor and Professor, University of Arizona, Department of Pharmacology and Toxicology, 1985-2000
  • Regents Professor, University of Arizona, Department of Pharmacology and Toxicology, 2000- 2005
  • Distinguished Professor, University of Kansas, Department of Medicinal Chemistry, August 2005-present

Awards/Honors/Activities

  • National Institutes of Health (NIH/NCCIH) National Advisory Council Member, 2018-2021
  • Fellow, American Society of Pharmacognosy, 2014
  • President, American Society of Pharmacognosy, 2011-2012
  • Honorary Member, American Society of Pharmacognosy, 2018
  • Inducted to Women's Hall of Fame, University of Kansas, 2014
  • Woman of Distinction, University of Kansas, August 2006
  • University Distinguished Professor, University of Kansas, May 2005-present
  • Chair, Department of Medicinal Chemistry, University of Kansas, 2005-2012
  • Director:
    • NIH Center of Biomedical Research Excellence (COBRE) Center for Cancer Experimental Therapeutics (CCET), 2005-2012
    • NIH International Cooperative Biodiversity Groups (ICBG) Program, 1993-2005
    • NIH Botanical Research Center, Arizona Center for Phytomedicine Research, 2000-2005
    • NIH Minority International Research Training (MIRT) Project, 2000-2005
    • USAID University Development Linkages Program USA-Chile ,1993-2000
  • Member, Editorial Board, Journal of Natural Products, 2002-present
  • National Institutes of Health (NIH/NCCAM), National Advisory Council Member, 2001-2005
  • Regents Professor, University of Arizona, February 2000
  • Fellow, American Association for the Advancement of Science (AAAS), February 2000
  • Member, Executive and Scientific Advisory Committees: AAAS Western Hemisphere Cooperation Program, 1992-2002
  • Research Support as PI: National Institutes of Health (NIH); National Science Foundation (NSF); US Department of Agriculture (USDA); US Agency for International Development (USAID); The John D. and Catherine T. MacArthur Foundation; Tinker Foundation; Arizona Disease Control Research Commission; Kansas Bioscience Authority; various pharmaceutical and chemical corporate grants.

Instruction

Arizona

  • PCOL 837 A, Medicinal Chemistry and Pharmacognosy
  • PCOL 837 B, Medicinal Chemistry and Pharmacognosy
  • PCOL 870, Phytomedicine
  • PCOL 820, Case Studies in Pharmacology
  • PCOL 821, Case Studies in Pharmacology
  • PHSC 632, Natural Medicinal Products
  • PLS 541, Economic Botany of Arid Lands
  • PCOL 195, Of People Plants and Medicine

Kansas

  • MDCM 626, Medicinal Chemistry II: Homeostatic Agents
  • MDCM 605, Phytomedicinal Agents I
  • MDCM 606, Phytomedicinal Agents II
  • MDCM 607, Clinical Pharmacognosy
  • MDCM 785, Natural Products of Medicinal Significance

Selected Publications (from more than 180)

Books (from 9)

Books (co-authored)

  • Yoshioka, H., T.J. Mabry and B.N. Timmermann. Sesquiterpene Lactones, Nuclear Magnetic Resonance, Chemistry and Distribution. The University of Tokyo Press, Tokyo, 1972, 544 pp.
  • Montenegro, G. and B.N. Timmermann. Chile, Nuestra Flora Util. Especies de uso Apicola, Alimentario en Medicina Folclorica, Artesanal y Ornamental. Abaco Press, Santiago, Chile, 2000, 284 pp.

Books (co-edited)

  • Timmermann, B.N., C. Steelink and F.A. Loewus. Recent Advances in Phytochemistry, Vol. 18. Phytochemical Adaptations to Stress. Plenum Press, New York, 1984, 334 pp.
  • Whitehead, E.E., C.F. Hutchinson, B.N. Timmermann and R.G. Varady. 1987. Arid Lands: Today and Tomorrow. Proceedings of an International Research and Development Conference. October 20-25, 1985. Westview Press, Boulder, Colorado. 1435 pp.

Chapters (from 18)

  • Timmermann, B.N. Biodiversity Prospecting in Drylands of Latin America in Combating Desertification with Plants, D. Pasternak and A. Schliessel (Eds.), pp 97-111, Kluwer Academic/Plenum Publishers, NY (2001).
  • Montenegro, G., Gomez, M.,Mujica, A.M., and Timmermann B.N. Theoretical Models for Regeneration of Medicinal Plants and Their Application in Sustainable Wild Harvesting. Pp 275-290 in: Lemons, J., R. Victor, and D. Schaffer (eds.), Conserving Biodiversity in Drylands: Best Practices in Developing Nations. Kluwer Academic Publishers, Norwell, MA 513 pgs. (2003).
  • Pfeiffer, E., H. Esch, S. Hohle, A. Solyom, B.N. Timmermann and M. Metzler. In vitro studies on the estrogenic activity and the metabolism of curcumin. In: Functional Foods: Safety Aspects (G. Eisenbrand, Ed). Deutsche Forschungsgemeinschaft, Senate Commission on Food Safety, Wiley-VCH Verlag, Weinheim, pp. 325-329 (2003).
  • Timmermann, B.N. Chemistry and Mechanisms of Action of Anti-Inflammatory Botanicals. Pp.95-102 in: Proceedings from the Eighth Shizuoka Forum on Health and Longevity, Biomedical and Sociological Approaches toward a Healthy Longevity-Society, Shizuoka, Japan, 175 pgs. (2004)
  • Timmermann, B.N. 2005. Biodiversity Prospecting in Drylands of Latin America. In Biodiversity & Health: Focusing Research to Policy. Proceedings of the International Symposium, held in Ottawa, Canada, October 25-28. Edited by J.T. Arnason, P.M. Catling, E. Small, P.T. Dang, and J.D.H. Lambert. NRC Research Press, Ottawa, Ontario. pp. 79-84. (2003).
  • Timmermann, B.N.; and Funk, J.L. Multidisciplinary Studies of Anti-Inflammatory Botanicals: Ginger and Turmeric, in Phytochemicals: Health Promotion and Therapeutic Potential. Proceedings of the Seventh International Phytochemical Conference, held in Buena Park, California, October 20-21, 2008. Edited by M.S. Meskin. CRC Press, Boca Raton, FL. (in press).

Peer-reviewed Publications (selected from a total of ca. 150 publications, ca. 50 within the last five years)

  • Valcic, S., B.N.Timmermann, D.S. Alberts, G.A. Wächter, M. Krutzsch, J. Wymer and J. Guillen. 1996. Inhibitory Effect of Six Green Tea Catechins and Caffeine on the Growth of Four Selected Human Tumor Cell Lines. Anti Cancer Drugs 7: 461-468. PMID: 8826614.
  • Gensler, H., B.N. Timmermann, S. Valcic and G. Wächter. 1996. Prevention of Photo-carcinogenesis by Topical Administration of Pure Epigallocatechin Gallate Isolated from Green Tea. Nutrition and Cancer 26(3): 325-335. PMID: 8910914.
  • Barthelman, M., W.B. Bair III, K.K. Stickland, W. Chen, B.N. Timmermann, S. Valcic, Z. Dong and G.T. Bowden. 1998. (-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity. Carcinogenesis. 19(12): 2201-2204. PMID: 9886579.
  • Chen, W., Z. Dong, S. Valcic, B.N. Timmermann and G.T. Bowden. 1999. Inhibition of Ultraviolet B-induced c-fos Gene Expression and p38 Mitogen-Activated Protein Kinase Activation by (-)-Epigallocatechin Gallate in a Human Keratinocyte Cell Line. Molecular Carcinogenesis 24(2): 79-84. PMID: 10078934.
  • Dvorakova, K., R.T. Dorr, S. Valcic, B.N.Timmermann and D.S. Alberts. 1999. Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin. Cancer Chemotherapy and Pharmacology 43: 331-335. PMID: 10071985.
  • Valcic, S., A. Muders, N.E. Jacobsen, D.L. Liebler, and B.N. Timmermann. 1999. Antioxidant chemistry of green tea catechins. Identification of products of EGCG reaction with peroxyl radicals. Chem. Res. in Toxicol. 12(4): 382 386. PMID: 10207128.
  • Waechter, G., S. Valcic, M.L. Flagg, S.G. Franzblau, G. Montenegro, E. Suarez and B.N. Timmermann. 1999. Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile. Phytomedicine 6(5): 341-345. PMID: 11962541.
  • Timmermann, B.N., G. Wachter, S. Valcic, B. Hutchinson, J. Henzel, C. Casler, S. Ram, F. Currim, R. Manak, S. Franzblau, W. Maiese, D. Galinis, E. Suarez, R. Fortunato, E. Saavedra, R. Bye, R. Mata and G. Montenegro. 1999.The Latin American ICBG: The First Five Years. Pharm. Biol. 37, Supplement, 35-54.
  • Valcic, S., J.A. Burr, B.N. Timmermann and D.C. Liebler. 2000. Antioxidant Chemistry of Green Tea Catechins. New oxidation products of (-)- epigallocatechin gallate and (-)- epigallocatechin from their reactions with peroxyl radicals. Chem. Res. Toxicol.13(A): 801-810. PMID: 10995252.
  • Gezginci, M.H. and B.N. Timmermann. 2001. A short synthetic route to nordihydroguaiaretic acid (NDGA) and its stereoisomer using Ti-induced carbonyl-coupling reaction.Tetrahedron Letters 42: 6083-6085.
  • Wachter, G., S.G. Franzblau, G. Montenegro, J.J. Hoffmann, W.M. Maiese and B.N. Timmermann. 2001. Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens. J. Nat. Prod. 64 (11): 1463-1464. PMID: 11720535.
  • Whitman, S., M. Gezginci, B.N. Timmermann & T.R. Holman. 2002. Structure-Activity Relationship Studies of Nordihydroguaiaretic Acid Inhibitors toward Soybean, 12-Human, and 15-Human Lipoxygenase. J. Med. Chem. 45(12), 2659-2661. PMID: 12036375.
  • Lambert, J.D., D. Zhao, R.O. Meyers, R.K. Kuester, B.N. Timmermann and R.T. Dorr. 2002. Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse. Toxicon 40: 1701-1708. PMID: 12457882.
  • Jolad, S., L.C. Lantz, A. M. Solyom, G.J. Chen, R.B. Bates, and B.N. Timmermann. 2004. Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production Phytochemistry 65:1937-1954. PMID: 15280001.
  • Lambert, J.D., Dorr, R.T., and Timmermann, B.N. 2004. Nordihydroguaiaretic Acid: A Review of its Numerous and Varied Biological Activities. Pharmaceutical Biology. 42(2): 149-158. PMID: 12457882.
  • Khera, S., Carducci, M., Michael, D., Gu, J Q., and Timmermann, B.N. 2004. (4R,5R,7S,8S,9S) 7 hydroxy 8 hydroxymethyl 4 methyl perhydrocyclopenta[c]pyran 1 one from Valeriana laxiflora. Acta Cryst.C60, o773 o775. PMID: 15528817.
  • Kiela, P.R., Midura, A.J., Kuscuoglu, N., Jolad, S.D., Solyom, A.M., Besselsen, D.G., Timmermann, B.N., and Ghishan, F.K. 2004. Boswellia serrata does not offer protection and is potentially hepatotoxic in mouse models of chemically induced colitis. Am J Physiol Gastrointest 288:G798-G808.
  • Mata, R., Morales, I., Perez, O., Rivero-Cruz, I., Acevedo, L., Enriquez-Mendoza, I., Bye, R., Franzblau, S.G., and Timmermann, B.N. 2004. Antimicrobacterial Compounds from Piper sanctum. J. Nat Prod 67(12): 1961-1968. PMID: 15620234.
  • Gu, J-Q., Wang, Y., Franzblau, S., and Timmermann, B.N. 2004. Constituents of Quinchamalium majus with Potential Antitubercular Activity. Z. Naturforsch 59(c), 797-802. PMID: 15666537.
  • Lambert, J.D., Sang, S., Dougherty, A., Caldwell, C.G., Meyers, R.O., Dorr, R.T., and Timmermann, B.N. 2005. Cytotoxic lignans from Larrea tridentata. Phytochemistry 66(7), 811-815. PMID: 15797607.
  • Jolad, S.D., Lantz, R.C., Solyom, A.M., Chen, C.J., Bates, R.B. and Timmermann, B.N. 2005.Commercially processed dry ginger (Zingiber officinale): Composition and effects on LPS-induced PGE2 production. Phytochemistry 66(13), 1614-1635. PMID: 15996695.
  • Jiang, H., A. Solyom, B. N. Timmermann, D. Gang. 2005. Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun.Mass Spectrom. 19, 2957-2964. PMID: 16189817.
  • Gutierrez-Lugo, M.T., Y. Wang, S. G. Franzblau, E. Suarez and B. N. Timmermann. 2005. Antitubercular sterols from Thalia multiflora Horkel ex Koernicke. Phytother. Res. 19, 876-880. PMID: 16261518.
  • Jiang, H., B. N. Timmermann and D. R. Gang. 2006. Use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (Curcuma longa L.) rhizome. J Chromat. A 1111, 21-31. PMID: 16490201.
  • Jiang, H., A. Somogyi, N.E. Jacobsen, B.N. Timmermann and D.R. Gang. 2006. Analysis of curcuminoids by positive and negative electrospray ionization and tandem mass spectrometry. 2006. Rapid Comm. Mass. Spectrom. 20, 1001-1012. PMID: 16479557.
  • Johnson, L., H. Strich, A. Taylor, B. Timmermann, D. Malone, N. Teufel-Shone, R. Drummond, R. Woosley, E. Pereira and A. Martinez. 2006. Use of herbal remedies by diabetic Hispanic women in the southwestern United States. Phytother. Res. 20, 250-255. PMID: 16557605.
  • Gu, J.-Q., Y. Wang, S.G. Franzblau, G. Montenegro and B. N. Timmermann. 2006. Dereplication of pentacyclic triterpenoids in plants by GC/MS. Phytochem. Anal. 17 (2), 102-106. PMID: 16634286.
  • Funk, J. L., J. N. Oyarzo, J. B. Frye, G. Chen, R. C. Lantz, S. D. Jolad, A. M. Solyom and B. N. Timmermann. 2006. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J. Nat. Prod. 69 (3), 351-355. PMID: 16562833.
  • Ramirez-Ahumada, M.C., B.N.Timmermann and D. R. Gang. 2006. Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases. Phytochemistry 67 (18), 2017-2029. PMID: 16890967.
  • Jiang, H., A. Somogyi, B.N. Timmermann and D.R. Gang. 2006. Instrument dependence of ESI ionization and MS/MS fragmentation of the gingerols. Rapid Comm. Mass Spectrom. 20 (20), 3089-3100. PMID: 16991102.
  • Uno, J.K., O.I. Kolek, E.R. Hines, H. Xu, B.N. Timmermann, P.R. Kiela and F. K. Ghishan. 2006. The role of tumor necrosis factor a in down-regulation of osteoblast Phex gene expression in experimental murine cholitis. Gastroenterology 131 (2), 497-509. PMID: 16890604.
  • Prudic, K. L.; Khera, S.; Solyom, A.; Timmermann, B. N. 2007. Isolation, identification, and quantification of potential defensive compounds in the viceroy butterfly and its larval host plant, Carolina willow. J. Chem. Ecol. 33(6): 1149-1159. PMID: 17431749.
  • Lantz, R. C.; Chen, G. J.; Sarihan, M.; Solyom, A. M.; Jolad, S. D.; Timmermann, B. N. 2007. The effect of extracts from ginger rhizhome on inflammatory mediator production. Phytomedicine 14: 123-128. PMID: 16709450.
  • Jiang, H.; Timmermann, B. N.; Gang, D. R. 2007. Characterization and identification of diarylheptanoids in ginger (Zingiber officinale Rosc.) using high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid. Commun. Mass. Spectrom. 21(4): 509-518. PMID: 17238228.
  • Billerey-Larmonier, C.; Uno, J. K.; Larmonier, N.; Midura, A. J.; Timmermann, B. N.; Ghishan, F. K.; Kiela, P. R. 2008. Protective effects of dietary curcumin in mouse model of chemically-induced colitis are strain dependent. J. Inflamm. Bowel Dis. 14(6): 780-793. PMID: 18200517
  • Funk, J. L.; Frye, J. B.; Oyarzo, J. N.; Timmermann, B. N. 2009. Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis. J. Nat. Prod. 72: 403-407. PMID: 1921655

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