Apurba Dutta

School of Pharmacy - Medicinal Chemistry
Associate Professor
Primary office:
785-864-4117
Malott Hall
Room 4001
University of Kansas
1251 Wescoe Hall Drive
Lawrence, KS 66045-7582


Associate Professor Apurba Dutta earned a Ph.D. from North-Eastern Hill University in Shillong, India in 1989 and was a post-doctoral fellow at the University of Konstanz in Germany from 1991-1992. He was also a post-doctoral fellow at the University of Kansas from 1993-1994.

Education

Ph.D., Synthetic Organic Chemistry, North-Eastern Hill University

M.S., Chemistry, North-Eastern Hill University

B.S., Chemistry, North-Eastern Hill University

Teaching Interests

  • Medicinal agents
  • Principles of drug design

Research

Organic Synthetic (including combinatorial synthesis) and Medicinal Chemical studies of bioactive compounds of natural and non-natural origin.

Biological research targets include, Proteasome (anti-cancer), Sphingolipids (anti-cancer), Chitin synthase (anti-fungal), HIV (anti-viral), and Endotoxin (anti-sepsis / anti-bacterial).

The compound classes of interest include, nucleosides, amino acids / peptides, carbohydrate / carbohydrate mimics, alkaloids, lipopolyamines, and aza-heterocyclics

Selected Publications

Pashikanti, S. Ukani, R. David, S. A., & Datta, A. (2017). Total Synthesis and Structure-Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine). Synthesis, 49(9), 2088-2100. DOI:10.1055/s-0036-1588118 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1588118

Foster, A. C., Li, Y. Runyan, S. Dinh, T. Venadas, S. Chen, J. Pashikanti, S. Dutta, A. Ehring, G. & Staubli, U. (2016). Activity of the enantiomers of erythro-3-hydroxyaspartate at glutamate transporters and NMDA receptors.

Selected Presentations

Datta, A. . (07/25/2015 - 07/25/2015). A serine-derived second-generation chiron: Applications in the synthesis of drug-like molecular scaffolds. India Global Pharma Expo & Summit 2015 (IGPES-2015). Hyderabad, India


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